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These are distributed across a wide variety of functional categories, including biosynthesis of cofactors, prosthetic groups and carriers, energy metabolism, DNA metabolism, purines, pyrimidines, nucleosides and nucleotides, transcription, protein synthesis, and protein fate. Figure 5 A CIM based on the TIGRFAM annotations selected on the first four components obtained through sPLS-DA (300, 210, 240, and 280 features selected respectively

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